Mthutuzeli Dudu Pukwana (18 July 1938 – 30 June 1990) was a South African saxophonist, composer and pianist (although not known for his piano playing).

Dudu Pukwana was born in Walmer Township, Port Elizabeth, South Africa. He grew up studying piano in his family, but in 1956 he switched to alto saxophoneafter meeting tenor saxophone player Nikele Moyake. In 1962, Pukwana won first prize at the Johannesburg Jazz Festival with Moyake’s Jazz Giants (1962 Gallo/Teal). In his early days he also played with Kippie Moeketsi. Chris McGregor then invited him to join the pioneering Blue Notes sextet, where he played along with Mongezi Feza, Nikele Moyake, Johnny Dyani and Louis Moholo. Although the Blue Notes are often considered McGregor’s group, Pukwana was initially the principal composer and all the group members had pivotal roles.