Willie Lee “Big Eyes” Smith (January 19, 1936 – September 16, 2011) was an American electric blues vocalist, harmonica player, and drummer. He was best known for several stints with the Muddy Waters band beginning in the early 1960s.

Born in Helena, Arkansas, Smith learned to play harmonica at age 17 after moving to Chicago, Illinois. His influences included listening to 78’s and the KFFA King Biscuit radio show, some of which were broadcast from Helena’s Miller Theater, where he saw guitar player Joe Willie Wilkins, and harmonica player Sonny Boy Williamson II. On a Chicago visit in 1953 his mother took him to hear Muddy Waters at the Zanzibar club, where Henry Strong’s harp playing inspired him to learn that instrument. In 1956, at the age of eighteen he formed a trio. He led the band on harp, Bobby Lee Burns played guitar and Clifton James was the drummer. As “Little Willie” Smith he played in the Rocket Four, led by blues guitarist Arthur “Big Boy” Spires, and made recordings that were later reissued on the Delmark label. In 1955 Smith played harmonica on Bo Diddley‘s recording of the Willie Dixon song “Diddy Wah Diddy” for the Checker label. Drummers were in more demand than harp players so Smith switched to drums and starting playing with Muddy Waters band. Smith recorded with Muddy on the 1960 album Muddy Waters Sings Big Bill Broonzy, a tribute to Big Bill Broonzy.