Charles Gayle (born February 28, 1939) is an American free jazz musician. Initially known as a saxophonist who came to prominence in the 1990s after decades of obscurity, Gayle also performs as pianist, bass clarinetist, bassist, and percussionist.

Charles Gayle was born in Buffalo, New York. Some of his history has been unclear due to his reluctance to talk about his life in interviews. He briefly taught music at the University at Buffalo before relocating to New York City during the early 1970s.