Jesse Fuller (March 12, 1896 – January 29, 1976) was an American one-man band musician, best known for his song “San Francisco Bay Blues“.

Fuller was born in Jonesboro, Georgia, near Atlanta. He was sent by his mother to live with foster parents when he was a young child, in a rural setting where he was badly mistreated. Growing up, he worked at numerous jobs: grazing cows for ten cents a day; working in a barrel factory, a broom factory, and a rock quarry; working on a railroad and for a streetcar company; shining shoes; and even peddling hand-carved wooden snakes. By the age of 10, he was playing the guitar in two techniques, which he described as “frailing” and “picking.”

In the 1920s he lived in southern California, where he operated a hot-dog stand and was befriended by Douglas Fairbanks. He worked briefly as a film extra in The Thief of Bagdad (1924) and East of Suez. In 1929 he settled in Oakland, across the bay from San Francisco, where he worked for the Southern Pacific Railroad for many years as a fireman, spike driver, and maintenance-of-way worker. He married, and he and his wife, Gertrude, had a family. During World War II, he worked as a shipyard welder, but when the war ended he found it increasingly difficult to secure employment. Around the early 1950s, Fuller began to consider the possibility of making a living as a musician.