Lloyd “Tiny” Grimes (July 7, 1916 – March 4, 1989) was an American jazz and R&B guitarist. He was a member of the Art Tatum Trio from 1943 to 1944, was a backing musician on recording sessions, and later led his own bands, including a recording session with Charlie Parker. He is notable for playing the electric tenor guitar, a four-stringed instrument.

Grimes was born in Newport News, Virginia, United States, and began his musical career playing drums and one-fingered piano. In 1938 he took up the electric four-string tenor guitar. In 1940 he joined the Cats and the Fiddle as guitarist and singer. In 1943 he joined the Art Tatum Trio as guitarist and made a number of recordings with Tatum.