Uri Caine (born June 8, 1956, Philadelphia, United States) is an American classical and jazz pianist and composer.

The son of Burton Caine, a professor at Temple Law School, and poet Shulamith Wechter Caine, Caine began playing piano at seven and studied with French jazz pianist Bernard Peiffer at 12. He later studied at the University of Pennsylvania, where he came under the tutelage of George Crumb. He also gained a greater familiarity with classical music in this period and worked at clubs in Philadelphia.

Caine played professionally after 1981, and by 1985 had his recording debut with the Rochester-Gerald Veasley band. In the 1980s, he moved to New York City, where he continues to live. His solo recording debut was in 1992. He also appeared on a klezmer album (Don Byron Plays the Music of Mickey Katz, 1993) and other recordings with modern jazz musicians Don Byron and Dave Douglas, among many others.