Fred McDowell (January 12, 1904 – July 3, 1972), known by his stage name Mississippi Fred McDowell, was an American hill country bluessinger and guitar player.

McDowell was born in Rossville, Tennessee, United States. His parents were farmers, who both died while Fred was in his youth. He took up the guitar at the age of 14 and was soon playing for tips at dances around Rossville. Seeking a change from plowing fields, he moved to Memphis in 1926, where he worked in the Buck-Eye feed mill, which processed cotton into oil and other products. In 1928, he moved to Mississippi to pick cotton. He finally settled in Como, Mississippi, in 1940 or 1941 (or maybe the late 1930s), where he worked as a full-time farmer for many years while continuing to play music on weekends at dances and picnics.