Biréli Lagrène (born 4 September 1966) is a French jazz guitarist who came to prominence in the 1980s for his Django Reinhardt–influenced style. He often performs in swing, jazz fusion, and post-bop styles.

Lagrène was born in Soufflenheim, Alsace, France, into a Romani family and community. His father and grandfather were guitarists, and he was raised in the Gypsy guitar tradition. He started playing at age four or five and by seven was improvising jazz in a style similar to that of Django Reinhardt, whom his father admired and wanted his sons to emulate. In 1980, while in his early teens, he recorded his first album, Routes to Django: Live at the Krokodil (Jazzpoint, 1981).

During the next few years, Lagrène toured with Al Di Meola, Paco de Lucía, and John McLaughlin, all of them guitarists, and played with Benny Carter, Benny Goodman, and Stéphane Grappelli. He joined Larry Coryell and Vic Juris in New York City for a tribute to Reinhardt in 1984 and went on tour with Coryell and Philip Catherine. He also performed with Jaco Pastorius, Stanley Clarke, the Gil Evans Orchestra, Christian Escoudé, and Charlie Haden. In 1989 he performed in a duo with Stanley Jordan.

His collaboration with Italian guitarist Giuseppe Continenza, with whom he has performed in numerous concerts and festivals, including the Pescara Jazz and the Eddie Lang Jazz Festival, began in 1998, when the two met behind the scenes of a festival and started talking about each other’s musical interests.