Frank Gambale born 22 December 1958) is an Australian jazz fusion guitarist. He has released twenty albums over a period of three decades, and is known for his use of the sweep picking and economy picking techniques.

Gambale graduated from the Guitar Institute of Technology in Hollywood with Student of the Year honors and taught there from 1984 to 1986.

With the Mark Varney Project, consisting of Allan Holdsworth, Brett Garsed, and Shawn Lane, he recorded two albums, Truth in Shredding (1990) and Centrifugal Funk (1991).