Mthutuzeli Dudu Pukwana (18 July 1938 – 30 June 1990) was a South African saxophonist and composer.

Dudu Pukwana was born in Walmer Township, Port Elizabeth, South Africa. He grew up studying piano in his family, but in 1956 he switched to alto saxophone after meeting tenor saxophone player Nikele Moyake. In 1962, Pukwana won first prize at the Johannesburg Jazz Festival with Moyake’s Jazz Giants (1962 Gallo/Teal). In his early days he also played with Kippie Moeketsi. Chris McGregor then invited him to join the pioneering Blue Notes sextet, where he played along with Mongezi Feza, Nikele Moyake, Johnny Dyani and Louis Moholo. Although the Blue Notes are often considered McGregor’s group, Pukwana was initially the principal composer and all the group members had pivotal roles.

As mixed-race groups were illegal under apartheid, the Blue Notes, increasingly harassed by authorities, emigrated to Europe in 1964, playing in France and Zürich, and eventually settling in London. After The Blue Notes split in the late 1960s, Pukwana joined McGregor’s Brotherhood of Breath big band, which again featured his soloing heavily. As a composer Pukwana wrote “Mra,” one of the best-loved tunes by the Brotherhood.