Carlos Humberto Santana Barragán (born July 20, 1947) is an American guitarist, best known as a founding member of the rock band Santana. Born and raised in Mexico where he developed his musical background, he rose to fame in the late 1960s and early 1970s in the United States with Santana, which pioneered a fusion of rock and roll and Latin American jazz. Its sound featured his melodic, blues-based lines set against Latin American and African rhythms played on percussion instruments not generally heard in rock, such as timbales and congas. He experienced a resurgence of popularity and critical acclaim in the late 1990s.

In 2015, Rolling Stone magazine listed Santana at No. 20 on their list of the 100 greatest guitarists. In 2023, Rolling Stone named him the 11th greatest guitarist of all time. He has won 10 Grammy Awards and three Latin Grammy Awards, and was inducted along with his namesake band into the Rock and Roll Hall of Fame in 1998.

Santana was born in Autlán de Navarro in Jalisco, Mexico on July 20, 1947. He learned to play the violin at age five and the guitar at age eight, under the tutelage of his father, who was a mariachi musician. His younger brother, Jorge, also became a professional guitarist.