John Cipollina (August 24, 1943 – May 29, 1989) was a guitarist best known for his role as a founder and the lead guitarist of the prominent San Francisco rock band Quicksilver Messenger Service. After leaving Quicksilver he formed the band Copperhead, was a member of the San Francisco All Stars and later played with numerous other bands.

Cipollina had a unique guitar sound, mixing solid state and vacuum-tube (valve) amplifiers as early as 1965. He is considered one of the fathers of the San Francisco sound, a form of psychedelic rock.

I like the rapid punch of solid-state for the bottom, and the rodent-gnawing distortion of the tubes on top.

To create his distinctive guitar sound, Cipollina developed a one-of-a-kind amplifier stack. His Gibson SG guitars had two pickups, one for bass and one for treble. The bass pickup fed into two Standel bass amps on the bottom of the stack, each equipped with two 15-inch speakers. The treble pickups fed two Fender amps: a Fender Twin Reverb and a Fender Dual Showman that drove six Wurlitzer horns. Cipollina died on May 29, 1989 at age 45. His cause of death was alpha-1 antitrypsin deficiency, which he suffered from most of his life and which is exacerbated by smoking.