Jimmy Hamilton (May 25, 1917 – September 20, 1994) was an American jazz clarinetist, tenor saxophonist, arranger, composer, and music educator, best known for his twenty-five years with Duke Ellington.

Hamilton was born in Dillon, South Carolina, and grew up in Philadelphia. Having originally learned to play piano and brass instruments, in the 1930s he started playing the latter in local bands, before switching to clarinet and saxophone. In 1939 he played with Lucky Millinder, Jimmy Mundy, and Bill Doggett, going on to join the Teddy Wilson sextet in 1940. After two years with Wilson, he played with Eddie Heywood and Yank Porter.

In 1943, he replaced Barney Bigard in the Duke Ellington orchestra, and stayed with Ellington until 1968. His style was very different on his two instruments: on tenor saxophone he had an R&B sound, while on clarinet he was much more precise and technical. He wrote some of his own material in his time with Ellington.