Major Merriweather (March 31, 1905 – February 23, 1953), better known as Big Maceo Merriweather, was an American pianist and blues singer. He was mainly active in Chicago through the 1940s.

Born in Newnan, Georgia, he was a self-taught pianist. In the 1920s, he moved to Detroit, Michigan, to begin his music career. He moved to Chicago in 1941, where he made the acquaintance of Tampa Red. Red introduced him to Lester Melrose of RCA Victor and its subsidiary label Bluebird Records, who signed Merriweather to a recording contract.

His first record was “Worried Life Blues” (1941), which became a blues hit and remained his signature piece. The song had elements derived from Sleepy John Estes‘ “Someday, Baby”. Other classic piano blues recordings followed, such as “Chicago Breakdown”, “Texas Stomp”, and “Detroit Jump“. His piano style was developed from players like Leroy Carr and Roosevelt Sykes and from the boogie-woogie style of Meade Lux Lewis and Albert Ammons. He in turn influenced other musicians, such as Little Johnny Jones and Henry Gray, the latter of whom credited Merriweather with helping him launch his career as a blues pianist.