Major Merriweather (March 31, 1905 – February 23, 1953), better known as Big Maceo Merriweather, was an American pianist and blues singer. He was mainly active in Chicago through the 1940s.

Born in Newnan, Georgia, he was a self-taught pianist. In the 1920s, he moved to Detroit, Michigan, to begin his music career. He moved to Chicago in 1941, where he made the acquaintance of Tampa Red.R ed introduced him to Lester Melrose of RCA Victor and its subsidiary label Bluebird Records, who signed Merriweather to a recording contract.