Biréli Lagrène (born 4 September 1966) is a French jazz guitarist. He came to prominence in the 1980s for his Django Reinhardt-influenced style. He often performs in swing, jazz fusion and post-bop styles.

Lagrène was born on 4 September 1966 in Saverne, Alsace, France, into a Romani family and community. His father and grandfather were guitarists, and he was raised in the gypsy guitar tradition. He started playing at age four or five, and by seven was improvising jazz in a style similar to Django Reinhardt‘s, who his father admired and wanted his sons to emulate. In 1980, while still in his early teens, he recorded his first album, Routes to Django: Live at the Krokodil (Jazz Point, 1981).