Frank Gambale (born 22 December 1958) is an Australian jazz fusion guitarist. He has released twenty albums over a period of three decades, and is known for his use of the sweep picking and economy picking techniques.

Gambale graduated from the Guitar Institute of Technology in Hollywood with Student of the Year honors and taught there from 1984 to 1986.

With the Mark Varney Project, consisting of Allan Holdsworth, Brett Garsed, and Shawn Lane, he recorded two albums, Truth in Shredding (1990) and Centrifugal Funk (1991). Beginning in 1987, he spent six years as a member of the Chick Corea Elektric Band, playing with Eric Marienthal, John Patitucci, and Dave Weckl. With Corea’s band he recorded five albums and shared two Grammy Award nominations. He spent twelve years as a member of Vital Information, led by Steve Smith. He reunited with the Elektric Band in 2002 and with Corea in 2011 when he joined Return to Forever IV with Stanley Clarke, Jean-Luc Ponty, and Lenny White.