Frank Isola (February 20, 1925 – December 12, 2004 in Detroit, Michigan) was an American jazz drummer.

Isola was born and raised in Detroit and was heavily influenced by Gene Krupa. He played in the U.S. military during World War II (1943–45), and then studied and performed in California with Bobby Sherwood and Earle Spencer. He then moved to New York City, where he played with Johnny Bothwell and Elliot Lawrence in 1947. Following this he played with Stan Getz (1951–53) and Gerry Mulligan (1953–54), as well as with Mose Allison, Eddie Bert, Bob Brookmeyer, Jimmy Raney, Johnny Williams and Tony Fruscella.