John Pisano (born February 6, 1931) is a jazz guitarist born in Staten Island, New York.

Pisano has accompanied in concert or recording Burt Bacharach, Tony Bennett, Herb Alpert, Natalie Cole, Michael Franks, Diana Krall, Peggy Lee, Julie London, Joe Pass, Frank Sinatra, Barbra Streisand, Billy Bean, and Chico Hamilton.