Lafayette Leake (June 1, 1919 – August 14, 1990) was an American blues and jazz pianist, organist, vocalist and composer who played for Chess Records as a session musician, and as a member of the Big Three Trio, during the formative years of Chicago blues. He played piano on many of Chuck Berry‘s recordings.

Leake was born in Winona, Missouri, United States, in 1919. Information about his early years is sparse, but in the early 1950s he joined the Big Three Trio (replacing Leonard Caston) and began his association with Chess Records, where he worked closely with bassist, producer, and songwriter Willie Dixon.