Matthew Tyler Murphy (December 29, 1929 – June 15, 2018), known as Matt “Guitar” Murphy, was an American blues guitarist. He was associated with Memphis Slim, The Blues Brothers and Howlin’ Wolf.

Murphy was born in Sunflower, Mississippi, and was educated in Memphis, Tennessee, where his father worked at the Peabody Hotel. Murphy learned to play guitar when he was a child.

In 1948, Murphy moved to Chicago, where he joined the Howlin’ Wolf Band, which at the time featured Little Junior Parker. In 1952, Murphy recorded with Little Junior Parker and Ike Turner, resulting in the release, “You’re My Angel”/“Bad Women, Bad Whiskey”(Modern 864), credited to Little Junior Parker and the Blue Flames.