James Wesley “Red” Holloway (May 31, 1927 – February 25, 2012) was an American jazz saxophonist.

Born in Helena, Arkansas, United States, Holloway started playing banjo and harmonica, switching to tenor saxophone when he was 12 years old. He graduated from DuSable High School, where he had played in the school big band with Johnny Griffin and Eugene Wright, and attended the Conservatory of Music, Chicago. He joined the Army when he was 19 and became bandmaster for the U.S. Fifth Army Band, and after completing his military service returned to Chicago and played with Yusef Lateef and Dexter Gordon, among others. In 1948, he joined blues vocalist Roosevelt Sykes, and later played with other rhythm & blues musicians such as Willie Dixon, Junior Parker, and Lloyd Price.

In the 1950s, he played in the Chicago area with Billie Holiday, Muddy Waters, Chuck Berry, Ben Webster, Jimmy Rushing, Arthur Prysock, Dakota Staton, Eddie “Cleanhead” Vinson, Wardell Gray, Sonny Rollins, Red Rodney, Lester Young, Joe Williams, Redd Foxx, B.B. King, Bobby Bland, and Aretha Franklin. During this period, he also toured with Sonny Stitt, Memphis Slim and Lionel Hampton. He became a member of the house band for Chance Records in 1952. He subsequently appeared on many recording sessions for the Chicago-based independents Parrot, United and States, and Vee-Jay.