“Big Eye” Louis Nelson Delisle (January 28, 1885 – August 20, 1949) was an American early twentieth-century Dixieland jazz clarinetist in New Orleans, Louisiana, United States. He also played double bass, banjo, and accordion.

Nelson Delisle was born into a family who were Creoles of color. He spent most of his life in New Orleans, Louisiana. He studied clarinet with the elder Lorenzo Tio.