Charles Douglas Musselwhite (born January 31, 1944) is an American blues harmonica player and bandleader, one who came to prominence, along with Mike Bloomfield, Paul Butterfield, and Elvin Bishop, as a pivotal figure in helping to revive the Chicago Blues movement of the 1960s. He has often been identified as a “white bluesman”. Musselwhite was reportedly the inspiration for Elwood Blues; the character played by Dan Aykroyd in the 1980 film, The Blues Brothers.

Musselwhite, whose father and paternal grandfather were also named Charlie Musselwhite (making him Charlie Musselwhite III), was born in Kosciusko, Mississippi to white parents. Originally claiming to be of partly Choctaw descent, in a 2005 interview he said his mother had told him he was of distant Cherokee descent. His family considered it natural to play music. His father played guitar and harmonica, his mother played piano, and a relative was a one-man band.