Cleopatra Brown (December 8, 1907 or 1909 – April 15, 1995), known as Cleo Brown, C. Patra Brown or Cleo Patra Brown, was an American blues and jazz vocalist and pianist. She was the first woman instrumentalist to receive the NEA Jazz Masters Fellowship

While Brown’s place of birth has been published as Meridian, Mississippi, Brown told W. Balliett in a 1986 interview published in The New Yorker that she was born in De Kalb, Mississippi, shortly before her father took a position as a pastor in Meridian. She played piano in the Baptist church as a child. In 1919 her family moved to Chicago, and she began learning piano from her brother who worked with “Pine Top” Smith, playing boogie-woogie for dances.From around 1923 she worked in vaudeville, as well as taking gigs in clubs. In 1935, she replaced Fats Waller as pianist on New York radio station WABC.