Eddie Henderson (born October 26, 1940) is an American jazz trumpet and flugelhorn player. He came to prominence in the early 1970s as a member of pianist Herbie Hancock‘s Mwandishi band, going on to lead his own electric/fusion groups through the decade. Henderson earned his medical degree and worked a parallel career as a psychiatrist and musician, turning back to acoustic jazz by the 1990s.

Henderson was born in New York City on October 26, 1940. At the age of nine he was given an informal lesson by Louis Armstrong, and he continued to study the instrument as a teenager in San Francisco, where he grew up, after his family moved there in 1954, at the San Francisco Conservatory of Music.

Henderson was influenced by the early fusion work of jazz musician Miles Davis, who was a friend of his parents. They met in 1957 when Henderson was aged seventeen.