Edward Jackson Henderson (born October 26, 1940) is an American jazz trumpet and flugelhorn player. He came to prominence in the early 1970s as a member of pianist Herbie Hancock‘s band, going on to lead his own electric/fusion groups through the decade. Henderson earned his medical degree and worked a parallel career as a psychiatrist and musician, turning back to acoustic jazz by the 1990s.

Henderson’s influences include Booker Little, Clifford Brown, Woody Shaw, and Miles Davis.

Henderson’s mother was one of the dancers in the original Cotton Club. She had a twin sister, and they were called The Brown Twins. They would dance with Bill “Bojangles” Robinson and the Nicholas Brothers. In the film showing Fats Waller playing “Ain’t Misbehavin'”, Henderson’s mother sat on the piano whilst Waller sang to her. His father sang with Billy Williams and The Charioteers, a popular singing group.