Frank Lowe (June 24, 1943 – September 19, 2003) was an American avant-garde jazz saxophonist and composer.

Born and brought up in Memphis, Tennessee, Lowe took up the tenor saxophone at the age of 12. As an adult he moved to San Francisco, where he met Ornette Coleman. Coleman suggested Lowe visit to New York City, which Lowe did, and he began playing with Sun Ra and then Alice Coltrane, with whom he recorded in 1971. Unusually for the jazz culture at the time, Lowe had had no extended apprenticeship or slow paying-of-dues: one moment he was an amateur, and the next he was playing with the late John Coltrane’s rhythm section. With Alice Coltrane he recorded World Galaxy in 1971.