Fred Wesley (born July 4, 1943) is an American jazz and funk trombonist, best known for his work with James Brown in the 1960s and 1970s, as well as Parliament-Funkadelic in the second half of the 1970s. In 2015, Wesley was inducted into the Alabama Jazz Hall of Fame.

Wesley was born the son of a high school teacher and big band leader in Columbus, Georgia, and raised in Mobile, Alabama. As a child he took piano and later trumpet lessons. He played baritone horn and trombone in school, and at around age 12 his father brought a trombone home, whereupon he switched (eventually permanently) to trombone.