Henry Grimes (November 3, 1935 – April 15, 2020) was an American jazz double bassist and violinist.

After more than a decade of activity and performance, notably as a leading bassist in free jazz, Grimes completely disappeared from the music scene by 1970. Grimes was often presumed to have died, but he was discovered in 2002 and returned to performing.

Henry Alonzo Grimes was born in Philadelphia, to parents who both had been musicians in their youth. He took up the violin at the age of 12, then began playing tuba, English horn, percussion, finally switching to the double bass at Mastbaum Technical High School. He furthered his musical studies at Juilliard and established a reputation as a versatile bassist by the mid-1950s. He recorded or performed with saxophonists Gerry Mulligan, Sonny Rollins, pianist Thelonious Monk, singer Anita O’Day, clarinetist Benny Goodman and many others.