Ike Isaacs (December 1, 1919, Rangoon, Burma – January 11, 1996, Sydney, Australia) was a jazz guitarist from Rangoon, Burma, best known for his work with violinist Stéphane Grappelli.

Isaacs was self taught on guitar. He started playing professionally in college while pursuing a degree in chemistry. In 1946 he moved to England, where he became a member of the BBC Show Band. During the 1960s and ’70s, he was a member of the Hot Club of London, led by guitarist Diz Disley, which often collaborated with Stéphane Grappelli. He was a member of the band Velvet with Digby Fairweather, Len Skeat, and Denny Wright. In the 1980s, he moved to Australia and taught at the Sydney School of Guitar.