Isaacs was self taught on guitar. He started playing professionally in college while pursuing a degree in chemistry. In 1946 he moved to England, where he became a member of the BBC Show Band. During the 1960s and ’70s, he was a member of the Hot Club of London, led by guitarist Diz Disley, which often collaborated with Stéphane Grappelli. He was a member of the band Velvet with Digby Fairweather, Len Skeat, and Denny Wright. In the 1980s, he moved to Australia and taught at the Sydney School of Guitar.
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