Mel Brown (October 7, 1939 – March 20, 2009) was an American-born blues guitarist and singer. He is best remembered for his decade long backing of Bobby Bland, although in his own right, Brown recorded over a dozen albums between 1967 and 2006.

Brown was born in Jackson, Mississippi, United States, and was presented with his first guitar as a teenager while recovering from a bout of meningitis. By 1955, after performing backing duties for both Sonny Boy Williamson II and Jimmy Beasley, Brown had a two year long stint backing Johnny Otis. This led to work with Etta James, where he swapped his Gibson Les Paul for an ES-175 to give him a richer and fuller tone to his guitar work, that set him apart from his contemporaries.