Wayne Escoffery (born 23 February 1975) is an American jazz saxophonist.

Since 2000, he has been working in New York City with Carl Allen, Eric Reed, and the Mingus Big Band. Other musicians performed with include Ralph Peterson, Ben Riley, Ron Carter, Rufus Reid, Bill Charlap, Bruce Barth, Jimmy Cobb, and Eddie Henderson. He has worked with vocalists including Mary Stallings, Cynthia Scott, Nancie Banks, LaVerne Butler, and Carolyn Leonhart. In addition to performing with his own Quartet featuring David Kikoski, Ugonna Okegwo and Ralph Peterson, Escoffery currently performs and tours with Ben Riley‘s Monk Legacy Septet, The Mingus Band, Ron Carter’s great Big Band, Monty Alexander, Amina Figarova and many others. He is currently a member of The Tom Harrell Quintet and has been since 2006. He has also co-produced four of Harrell’s latest recordings.

Wayne and his mother, Patricia Escoffery emigrated to the United States and settled in New Haven, Connecticut in 1986. He attended ACES Educational Center for the Arts high school.