Wayne Escoffery (born 23 February 1975 in London, England) is a jazz saxophonist based in New York City.

Since 2000, he has been working in New York City with Carl Allen, Eric Reed, and the Mingus Big Band. Other musicians performed with include Ralph Peterson, Ben Riley, Ron Carter, Rufus Reid, Bill Charlap, Bruce Barth, Jimmy Cobb, and Eddie Henderson. He has worked with vocalists including Mary Stallings, Cynthia Scott, Nancie Banks, LaVerne Butler, and Carolyn Leonhart.