John Cipollina (August 24, 1943 – May 29, 1989) was a guitarist best known for his role as a founder and the lead guitarist of the prominent San Francisco rock band Quicksilver Messenger Service. After leaving Quicksilver he formed the band Copperhead, was a member of the San Francisco All Stars and later played with numerous other bands.

John and his twin sister Manuela were born in Berkeley, California, on August 24, 1943. Cipollina attended Tamalpais High School, in Mill Valley, California, as did his brother, Mario (born 1954), and sister, Antonia (born 1952). Their father, Gino, was of Italian ancestry (Genovese and Piemontese origins). He was a realtor, and their mother, Evelyn, and godfather, José Iturbi, were concert pianists.